ABSTRACT
Unfractionated heparin is the most commonly used anticoagulant for hemodialysis (HD). It is well-known that heparin can cause immune-mediated thrombocytopenia due to immunoglobulin antibody formation against the complex of platelet factor 4 (PF4) and heparin. Heparin may also contribute to HD-associated platelet activation, thrombocytopenia, and increased PF4 release from platelets during a heparin dialytic session. The present study was conducted to study the effect of unfraction heparin as anticoagulant in newly treatment hemodialysis patients. Material and method: A sample of 72 people were selected, 32 patients on dialysis for first time from unite of kidney dialysis. At the same time a group of 40 randomly selected healthy adults to participate in the study as control. By Automated cell counter (sysmex X 21) platelets from all patients on dialysis before starting heparin and after one month later were estimated. Result: The mean value of platelets in patients after treated with heparin was significant lower (192.3 ± 20.7 ) × 109/l as compare before treated with heparin 203 ± 20.7 × 109/l ( P = 0.001). Conclusion: From this study, heparin as anti-coagulant has effect on decrease platelets count but still patients have no thrombocytopenia platelets level ≥ 150 × 109/l.
ABSTRACT
Diabetes mellitus contributes for initiation and progression of micro vascular and macro vascular complications. Complication includes coagulation impairment however Shortened activated partial thromboplastin time (aPTT) values may reflect hypercoaguable state, which is associated with increased thrombotic risk and adverse cardiovascular events. Objective: The present study was conducted to study the aPTT and PT levels in patients with diabetes mellitus type II. Material and method: A sample of 50 persons were selected, 30 patients suffering from DM as type II from Al-wahda teaching hospital, Derna-Libya. At the same time a group of 20 randomly selected healthy adults to participate in the study as control group. Result: The mean value of APTT in T2DM individuals was significant lower (28.95 ±7.54) seconds as compare with control, (34.12±2.82) seconds (P = 0.06). The mean value of prothrombin time (PT) among T2DM individuals was (14.04 ±2.96) seconds and the mean value of PT among healthy individuals was (13.5 ± 1.54) seconds. There was no significant difference in PT of T2DM individuals P ≥ 0.05. Conclusion: From this study, it may be concluded that shorted APTT confirms that T2DM is a hyper-coagulable state due to which there is increased risk of thrombotic events.
ABSTRACT
Thrombocytopenia is a common finding in pregnancy, occurring in approximately 10 – 16 % of women. The normal range of platelet counts decreases, and it is not uncommon for the platelet counts to decrease as pregnancy progresses. Lower platelet count observed in the pregnant are due to normal physiologic changes, and has many common causes including gestational thrombocytopenia, viral and bacterial infection and preeclampsia complicated by hemolysis. Objective: the objective was to investigate thrombocytopenia during different stages of pregnancy. Materials and methods: Sixty three pregnant women were included in this study from different clinic in Derna city. Mean age (28 ± 1.4) year with a range (20 – 1.4) year. At the same time a group of Sixty three healthy non pregnant women mean age ( 29 ± 2.2 ) with a range ( 23 – 45 ) year to compare platelets count between them. By automated cell counter platelets from all pregnant and non pregnant were estimated. Results: Pregnant women had lower platelets count (mean 193× 109/l) as compared to healthy non pregnant women (mean 250 × 109/l). There was significant decrease in platelet count in pregnant as compare with non pregnant P ≤ 0.001. Conclusion: Platelet counts were performed on sixty three normal patients at different stages of pregnancy. Patients with complications of pregnancy known to influence the platelet count were excluded from the study. There was significant decrease in platelet count during pregnancy.